Which enzyme increases with cholestasis in dogs and cats?

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Multiple Choice

Which enzyme increases with cholestasis in dogs and cats?

Explanation:
Cholestasis, or impaired bile flow, triggers a rise in enzymes that come from the biliary system. Alkaline phosphatase is concentrated in the membranes of bile canaliculi and bile ducts, so when bile flow is obstructed these cells produce and release more ALP into the blood. That makes serum ALP a classic marker of cholestasis in dogs and cats. ALT and AST reflect general hepatocellular injury rather than the biliary obstruction itself, so they aren’t as indicative of cholestasis. Gamma-glutamyl transferase also increases with biliary obstruction and can be helpful, especially in cats, but ALP is the most consistently elevated enzyme pattern associated with cholestasis.

Cholestasis, or impaired bile flow, triggers a rise in enzymes that come from the biliary system. Alkaline phosphatase is concentrated in the membranes of bile canaliculi and bile ducts, so when bile flow is obstructed these cells produce and release more ALP into the blood. That makes serum ALP a classic marker of cholestasis in dogs and cats.

ALT and AST reflect general hepatocellular injury rather than the biliary obstruction itself, so they aren’t as indicative of cholestasis. Gamma-glutamyl transferase also increases with biliary obstruction and can be helpful, especially in cats, but ALP is the most consistently elevated enzyme pattern associated with cholestasis.

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